Journalist Raoul Duke (Johnny Depp), with his ( very sharp) knife-wielding lawyer Dr Gonzo (Benicio del Toro) at his side, a loyal ally in their war against grotesque humanity (well, until the drugs kick in and the paranoia starts, then all bets are off), whose primary advise for Duke is to join him in consuming massive quantities of illegal substances (be they uppers, downers, psychedelics, or any other mind-altering chemicals, including eventually some kind of adrenal fluid the good attorney claims was extracted from a live victim that Duke ends up taking way too much of – not that either of them are particularly moderate with anything else out of Gonzo’s impressively loaded briefcase) speed, convertible-style, across the desert to Las Vegas with the goal of ostensibly covering a popular motorcycle race.
Fear and Loathing in Las Vegas (Terry Gilliam, 1998)